Acetaminophen and aspirin toxicity are both high yield, but the injury pattern is very different. Acetaminophen overdose overwhelms glutathione, allowing NAPQI to build up and cause hepatic necrosis. The antidote is N acetylcysteine, which Oxidative stress mediates end organ damage in a novel model of acetaminophen toxicity in Drosophila Scientific Reports Acetaminophen Intoxication: A Critical Care Emergency Xia & He Publishing
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glutathione and tylenol toxicity Sex differences in glutathione metabolism and acetaminophen toxicity