Too Much of a Good Thing: Inadvertent Acetaminophen Overdose in a Low Weight, Elderly Patient Silymarin prevents acetaminophen induced hepatotoxicity via up regulation of the glutathione conjugation capacity in mice ScienceDirect Tylenol's Impact on Glutathione and Liver Damage Acetaminophen and aspirin toxicity are both high yield, but the injury pattern is very different. Acetaminophen overdose overwhelms glutathione, allowing NAPQI to build up and cause hepatic necrosis. The antidote is N acetylcysteine, which