Elevated glutathione levels may reflect an accumulation resulting from impaired recycling, often due to deficiencies in NADPH, selenium, or riboflavin (vitamin B2). This indicates a disruption in the redox balance rather than Riboflavin deficiency alters cholesterol homeostasis partly by reducing apolipoprotein B100 synthesis in HepG2 cells International Journal for Vitamin and Nutrition Research Elemental Selenium and Vitamin B2 (riboflavin) are essential for glutathione use and recycling. Selenium is really low in Australian soils, and people are commonly deficient. Signs of low B2 are blood Riboflavin for women's health and emerging microbiome strategies npj Biofilms and Microbiomes