g glutamyl cycle. Depletion of glutathione by acetaminophen leads to Download Scientific Diagram Is Tylenol Safe During Pregnancy? Risk Factors, Not Causation Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Acetaminophen induces liver injury and depletes glutathione in mice brain: Prevention by Moringa oleifera extract ScienceDirect