Does B12 Cause Acne? (HINT: It Depends) I thought this would be an impossible case. Sara has a health condition that requires a Vitamin B12 injection every 3 weeksa tough challenge for acne prone skin, as B12 is notorious for Is B12 making you break out? It's possible. We've found in our own experience and in clinical studies that certain forms of vitamin B12 can trigger inflammatory acne for some individuals. Too Much Vitamin B12 Linked to Acne Live Science
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