Please hear my heart here! There's no judgment from me, but this info is important and definitely not something widely talked about! It is very common advice parents receive to just give Tylenol Avoid or Not to Avoid? Acetaminophen (Tylenol) can deplete glutathione, your body's most important detox antioxidant. This matters even more if your child has an MTHFR gene mutation, which ACETAMINOPHEN INDUCED HEPATIC NECROSIS. IV. PROTECTIVE ROLE OF GLUTATHIONE The Journal of Pharmacology and Experimental Therapeutics Early life acetaminophen exposure, glutathione S transferase genes, and development of adolescent asthma in a high risk birth cohort Journal of Allergy and Clinical Immunology