Man Concerned About a New Spot On His Lip Let's Diagnose VisualDx Labial Lentigo (labial melanotic macule) Cancer Therapy Advisor Labial Lentigo (labial melanotic macule) Cancer Therapy Advisor Melanotic macule. Benign. Dark spot on labia (or lip). Analogous to lentigo simplex. Hyperpigmented basal keratinocytes & dermal melanophages. Slight in single basal melanocytes; NO nests. More info like this in
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