Chronic Glutathione Depletion Confers Protection against Alcohol induced Steatosis: Implication for Redox Activation of AMP activated Protein Kinase Pathway Scientific Reports Glutathione is such a critical soldier in our line of defense that our bodies make it themselves. We even have mechanisms that recycle and reuse it. But what happens when our toxic Acetylcysteine (N acetylcysteine, NAC) for the management of non acetaminophen induced acute liver failure Dysregulation of glutathione synthesis in liver disease ScienceDirect