Glutathione You Are The Healer The mechanism of acetaminophen action! The mechanism of action of acetaminophen (paracetamol), a common analgesic, is not yet clear. The study shows that acetaminophen counterintuitively inhibits diacylglycerol lipase (DAGL), but not comment LINK if you want the link to the supplements in this post : Tylenol Acetaminophen Paracetamol is the most widely used over the counter anti fever and anti pain drug in children. It is well tolerated Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors.