A 48 hour fast can turn standard Paracetamol into acute liver failure. Fasting depletes Glutathione, leaving the liver defenseless against toxic NAPQI. Review the latest guidelines on BMJ Best Practice: https: bestpractice.bmj.com topics en us 1010 Cystathionine Lyase Protects Against Choline Deficient High Fat Diet Induced Metabolic Dysfunction Associated Steatotic Liver Disease Through the CysteineGlutathione Axis in Mice Min Ji Kim, You Ri Park, Gibong Jang, Yong Kwon Han, Isao Ishii, Glutathione and Toxicology and Liver Disease Glutathione Reporter Glutathione is such a critical soldier in our line of defense that our bodies make it themselves. We even have mechanisms that recycle and reuse it. But what happens when our toxic