While coffee enemas have gained popularity as a wellness trend, it's important to note that there is no scientific evidence to support their effectiveness. Stick to a cup of joe or a Antioxidant effects after coffee enema or oral coffee consumption in healthy Thai male volunteers Semantic Scholar Trust Your Gut Enema Coffee Bethany's Pantry Glutathione prevents high glucose induced pancreatic fibrosis by suppressing pancreatic stellate cell activation via the ROS TGF SMAD pathway Cell Death & Disease