Gut Microbiota and Ischemic Stroke: The Role of Trimethylamine N Oxide Frontiers The gut microbial metabolite trimethylamine N oxide and cardiovascular diseases The Intricate Gut Heart Connection; The Role of Gut Microbiota in the Pathogenesis of Cardiovascular Disease Trimethylamine N oxide (TMAO) is a small molecule produced in humans primarily by the gut liver axis and has become an important biomarker, and possible mediator, of cardiometabolic and renal disease. Dietary choline, phosphatidylcholine (
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