Pharmacology of paracetamol Deranged Physiology At *therapeutic* doses, what is the primary metabolic pathway for acetaminophen (paracetamol)? Phase II conjugation (glucuronidation and sulfation) Phase I oxidation by CYP3A4 Phase I oxidation by CYP2E1 Direct excretion by the Liver injury induced by paracetamol and challenges associated with intentional and unintentional use Acetaminophen Toxicity Emergency Physicians Monthly
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acetaminophen glutathione conjugation Acetaminophen–glutathione conjugate formation in a coupled cytochrome P-450- glutathione S-transferase assay system mediated by subcellular preparations from adult and weanling rat tissues