Acetaminophen Toxicity in Children: Diagnosis, Clinical Assessment, and Treatment of Acute Overingestion Consultant360 Can I give Tylenol (acetaminophen) to a patient with elevated aspartate aminotransferase (AST) alanine aminotransferase (ALT) levels? Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. The Acetaminophen Molecule Tylenol