Paracetamol toxicity Deranged Physiology Unveiling the molecular basis of paracetamol induced hepatotoxicity: Interaction of N acetyl p benzoquinone imine with mitochondrial succinate dehydrogenase ScienceDirect Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Ferroptosis and Intrinsic Drug induced Liver Injury by Acetaminophen and Other Drugs: A Critical Evaluation and Historical Perspective