Prefrontal Glutathione Levels in Major Depressive Disorder Are Linked to a Lack of Positive Affect Do You Know About The Master Antioxidant? Dr. Shel Wellness & Aesthetic Center A major breakthrough in brain science is shedding new light on the biology behind depression. Using advanced imaging, researchers have found that people with major depressive disorder have significantly lower levels of Neuronal glutathione loss leads to neurodegeneration involving gasdermin activation Scientific Reports