If supplements seem to make you feel worse instead of better, you're not imagining it! Many of the supplements most commonly recommended for detox, gut health, or methylation can actually activate mast Clinical Glutathione EuroMedica Glutathione: Why is it important for detox & how to improve the amount in your body RealTime Laboratories Mast cells are hypersensitive immune cells that release histamine and other inflammatory mediatorsoften in response to oxidative stress, environmental toxins, and immune imbalance. Many patients with MCAS have low levels of glutathione.