What To Avoid When Taking Glutathione Glutathione Deficiency Symptoms: Is Poor Sleep Just the Beginning? Cardiology & Neurology Specialists located in Queens, Forest Hills and Brighton Beach, Brooklyn, NY Advanced Medical Care Your liver's unsung hero: Glutathione Let's talk about what really happens when you take Tylenol (acetaminophen). Your liver breaks down acetaminophen through several pathways. One pathway creates NAPQIa reactive compound that needs Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: