Metabolism: The pentose phosphate pathway and G6PD deficiency (practice) Khan Academy Pentose Phosphate Pathway made simple. This pathway has two major jobs: Generate NADPH Produce ribose 5 phosphate NADPH protects cells from oxidative stress and supports fatty acid, cholesterol, steroid, nitric oxide, and respiratory burst A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway Nature Chemical Biology Pentose Phosphate Pathway (PPP), Purine and Pyrimidine Metabolism Cell Biology, Genetics, and Biochemistry for Pre Clinical Students