Did you know? Many commonly prescribed medications can quietly deplete your body of essential nutrients and most people are never told! From birth control to statins and acid blockers, these medications Toxins and Methylation Glutathione & Copper Overload Pathways Does ibuprofen deplete glutathione? Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors.