Peptide Therapy 101: Can BPC 157 & Thymosin Beta 4 Accelerate Ortho Recovery? Peptides are often well tolerated, but they can still cause temporary reactions while the body adapts. Some commonly reported effects include: BPC 157 headaches, nausea, increased appetite TB 500 Peptide side effects no one talks about BPC 157 headaches. TB 500 fatigue. CJC Ipamorelin water retention. Most people quit. But 90% of the time it's the protocol, not the peptide. TB 500 vs BPC 157: Comprehensive comparison of healing peptides