Hepatic Glutathione Synthesis: The Liver's Antioxidant Powerhouse Glutathione (GSH) is the most abundant intracellular antioxidantand the liver is its primary production site. Through a tightly regulated, ATP dependent pathway, hepatocytes An Example of a Drug That Causes Toxicity Through the Formation of a Chemically Reactive Intermediate Mechanisms of Adverse Drug Reactions Pharmacovigilance Nonalcoholic Fatty Liver Disease New England Journal of Medicine Glutathione is known as the master antioxidant. This critical compound protects cells from damage caused by free radicals and toxins, supports detoxification, plays a key role in DNA synthesis and repair,