Glutathione Synthetase Deficiency as a Cause of Hereditary Hemolytic Disease Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: Master Antioxidant" Glutathione Affected by Vitamin D Status GrassrootsHealth The glutathione peroxidase Gpx4 prevents lipid peroxidation and ferroptosis to sustain Treg cell activation and suppression of antitumor immunity: Cell Reports