When people think about detox, they usually think about the liver. But detoxification actually involves several systems working together. One of the most important is methylation. Methylation supports processes involved in Methyl donor supplementation reduces phosphoTau, Fyn and demethylated protein phosphatase 2A levels and mitigates learning and motor deficits in a mouse model of tauopathy Hummel 2023 Neuropathology and Applied Transsulfuration Activity Can Support Cell Growth upon Extracellular Cysteine Limitation: Cell Metabolism Methylation cycle hypothesis MEpedia