Trimethylamine N oxide (TMAO) is a small molecule produced in humans primarily by the gut liver axis and has become an important biomarker, and possible mediator, of cardiometabolic and renal disease. Dietary choline, phosphatidylcholine ( Unraveling the Formation Mechanisms of Trimethylamine N Oxide and Its Inhibition by Food Ingredients: Toward Cardioprotective Food Development Journal of Agricultural and Food Chemistry Gut microbe derived metabolite trimethylamine N oxide activates PERK to drive fibrogenic mesenchymal differentiation: iScience Dietary allicin reduces transformation of L carnitine to TMAO through impact on gut microbiota ScienceDirect
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l carnitine tmao Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis