Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. PurePath Detox System 2 Part Cellular & Body Cleanse with Milk Thistle, Glutathione & Activated Charcoal MaxLiving Store Glutathione an overview ScienceDirect Topics The reason some people stay sick despite treatment often comes down to one molecule. Glutathione is the most abundant antioxidant inside your cells. It protects mitochondria, recycles other antioxidants, and repairs