Labial or Oral Melanotic Macule Benign, asymptomatic, and often underdiagnosed. Swipe to learn how to recognize, diagnose, and manage this simple yet important lesion! #thebasicdentist #rguhs #kuhs #tnmgrmu #OralPathology #MelanoticMacule #DentalFacts Definition of melanocytic macules associated with Peutz Jeghers syndrome NCI Dictionary of Genetics Terms NCI Melanotic Macules, Naevi, and Melanoma Springer Nature Link Brown spots, especially on the lips, can be alarming to some. In some instances it can indicate rare oral mucosal melanoma, however in this case it was a non cancerous labial melanotic macule.