Evaluation of Metabolically Stabilized Angiotensin IV Analogs as Procognitive Antidementia Agents The Journal of Pharmacology and Experimental Therapeutics Epithalon (Epitalon) Simon's Compounding Dihexa (also known as PNB 0408) is an experimental small molecule derived from angiotensin IV. It was engineered to cross the bloodbrain barrier and has shown synaptogenic effects in preclinical models. The often quoted Stronger association of intact angiotensinogen with mortality than lactate or renin in critical illness: post hoc analysis from the VICTAS trial Critical Care Springer Nature Link